The appearance of a rash in cancer patients treated with erlotinib (Tarceva) is strongly linked to longer survival, as per scientists from the drug’s developer, OSI Pharmaceuticals, Inc. This is not the first time that rash has been linked to a survival advantage with EGFR inhibitors – a class of drugs which includes erlotinib, cetuximab, panitumumab and others designed to block overproduction of the epidermal growth factor receptor – but it is the most detailed analysis to date.
The study, reported in the July 1 issue of Clinical Cancer Research, a journal of the American Association for Cancer Research, reports that for patients taking Tarceva who developed a moderate to severe rash, survival without progression of disease was 245 percent longer than in patients who had a mild rash or none at all. In fact, in the majority of cases, the more severe the rash, the longer a patient’s cancer was held in check, scientists found.
This rash, which often looks like acne, can be unpleasant enough for some people to consider discontinuing therapy, but “it is important for physicians and patients to understand that this a positive event because it means there is likely to be a better clinical outcome,” said the lead author, Bret Wacker, MS Director of Biostatistics at OSI Pharmaceuticals, Inc. “Further studies are needed to both identify patients most likely to develop rash and to determine if dose escalation to induce rash can improve efficacy.”
Eventhough few patients dropped out of the large Phase III clinical trials testing Tarceva in advanced non-small cell lung cancer and pancreas cancer due to the rash, Wacker said he fears those who are taking Tarceva outside of a clinical trial may be likely to stop therapy.
“Some patients are stopping therapy because of the rash, yet those are the ones who are most likely to benefit,” Wacker said. “This is a critical problem and rather than permanently discontinue therapy, patients should talk to their doctor about an effective and proactive strategy to manage the rash while continuing Tarceva treatment.”
As per the researchers, these rashes can be controlled with mild steroids or antibiotics, and in most cases, they will improve with therapy. They are thought to bedue to an inflammatory response as a result of EGFR inhibition in skin tissue, Wacker said.
The analysis looked at two placebo-controlled, double-blind, randomized, Phase III clinical trials testing Tarceva in advanced non-small cell lung cancer and pancreas cancer – studies which led to approval of the agent for treating both cancers. Wacker and his team excluded patients who died in the first month after starting the study because they may not have had time to develop the rash or the rash may have been under-published in these ill patients.
Of the 673 patients in the lung cancer study, called BR.21, and in the Tarceva-treated group, 81 percent developed a rash, the majority of which was grade 2 (The study graded rashes from 1, relatively mild, to 4, severe). The scientists observed that the presence of any rash correlated with overall and progression-free survival and that these correlations increased with the grade of rash. Specifically, Tarceva-treated patients who did not develop a rash survived a median of 3.3 months, in comparison to 7.1 months for those with a grade 1 rash, and 11.1 months for patients with more severe, grade 2 rashes.
They also found, however, that 18 percent of patients treated with a placebo also developed a rash, and that overall survival in these patients was also significantly longer (a median of 8.2 months in comparison to 4.7 months), in comparison to placebo patients who didn’t develop a rash. “We don’t know why some patients treated with a placebo developed a rash, but it could be due to the strength of their immune system, and that is why they survived longer,” Wacker said.
In the second clinical trial (known as PA.3) that tested Tarceva and the chemotherapy drug gemcitabine against a placebo drug and gemcitabine in 521 patients with advanced pancreas cancer, 71 percent of patients using Tarceva/gemcitabine developed a rash, compared with 30 percent of patients in the placebo group.
This increased rate of rashes in the placebo group makes some sense, Wacker said, because rashes are known to occur with use of gemcitabine chemotherapy. But, unlike the BR.21 study, these pancreas cancer patients with rashes in the placebo group did not experience an increase in survival in comparison to placebo group patients without a rash.
In the Tarceva therapy group, only a more severe rash of grade 2 or higher was linked to increased survival. Patients with a grade 2 rash survived a median of 10.8 months, in comparison to treated patients with no rash (5.4 months) or a grade 1 rash (5.7 months). “These different results may be linked to the addition of gemcitabine with Tarceva, or the lower dose of Tarceva in this study, but we just don’t know,” he said.
Wacker points out that lack of a rash doesn’t necessarily mean that patients will not benefit from Tarceva. “A small percentage of patients who didn’t develop a rash still had relatively long survival,” he said. “But, still, overall, patients who don’t develop a rash don’t do as well as those who do.”